Peschke® Riboflavin Solutions

The Hypotonic Riboflavin Solution with Dextran (1.5 ml) is a specialized ophthalmic solution formulated for corneal cross-linking (CXL) procedures in patients with thin corneas. Designed specifically for cases where baseline corneal thickness is under $400\ \mu\text{m}$, this hypotonic solution utilizes osmotic action to swell the corneal stroma to a safe thickness before UV-A irradiation, protecting underlying ocular structures such as the endothelium.

Key Features & Clinical Benefits

1. Targeted Hypotonic Osmotic Effect: Engineered to safely swell thin corneas (< 400 Mm). to the recommended minimum safety threshold prior to cross-linking irradiation.
2. Optimal Riboflavin Concentration: Contains 0.1% Riboflavin (Vitamin B2) to facilitate effective photo-polymerization under UV-A light.
3. Pre-Loaded Glass Syringe: Delivered in a sterile 1.5 ml pre-loaded glass syringe for convenient, precise, and aseptic instillation in the operating room.
4. Endothelial Protection: Increases corneal thickness to shield the corneal endothelium, anterior chamber, and crystalline lens from UV-A phototoxicity.

Application Protocol & Instillation Guidelines

1. Target Patient Profile: Patients undergoing CXL with thin corneal thickness (< 400 Mm).
2. Recommended Instillation Rate: Instill 1 drop every 5 seconds onto the corneal bed.
3. Treatment Goal: Continue drop instillation until pachymetry confirms that corneal thickness has reached at least 400 Mm

Technical & Ingredient Specifications

1. Active Ingredient: 0.1\% Riboflavin (Vitamin B2)
2. Additive / Carrier: Dextran formulation (Hypotonic)
3. Packaging: 1.5 ml liquid in a pre-loaded glass syringe
4. Primary Function: Osmotic corneal swelling & photosensitization